2,225 research outputs found

    Transferring Collective Knowledge: Collective and Fragmented Teaching and Learning in the Chinese Auto Industry

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    Collective knowledge, consisting of tacit group-embedded knowledge, is a key element of organizational capabilities. This study undertakes a multiple-case study of the transfer of collective knowledge, guided by a set of tentative constructs and propositions derived from organizational learning theory. By focusing on the group-embeddedness dimension of collective knowledge, we direct our attention to the source and recipient communities. We identify two sets of strategic choices concerning the transfer of collective knowledge: collective vs. fragmented teaching, and collective vs. fragmented learning. The empirical context of this study is international R&D capability transfer in the Chinese auto industry. From the case evidence, we find the expected benefits of collective teaching and collective learning, and also discover additional benefits of these two strategies, including the creation of a bridge network communication infrastructure. The study disclosed other conditions underlying the choice of strategies of transferring collective knowledge, including transfer effort and the level of group-embeddedness of the knowledge to be taught or re-embedded. The paper provides a group-level perspective in understanding organizational capabilities, as well as a set of refined constructs and propositions concerning strategic choices of transferring collective knowledge. The study also provides a rich description of the best practices and lessons learned in transferring organizational capabilities.http://deepblue.lib.umich.edu/bitstream/2027.42/39804/3/wp420.pd

    Transferring Collective Knowledge: Collective and Fragmented Teaching and Learning in the Chinese Auto Industry

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    Collective knowledge, consisting of tacit group-embedded knowledge, is a key element of organizational capabilities. This study undertakes a multiple-case study of the transfer of collective knowledge, guided by a set of tentative constructs and propositions derived from organizational learning theory. By focusing on the group-embeddedness dimension of collective knowledge, we direct our attention to the source and recipient communities. We identify two sets of strategic choices concerning the transfer of collective knowledge: collective vs. fragmented teaching, and collective vs. fragmented learning. The empirical context of this study is international R&D capability transfer in the Chinese auto industry. From the case evidence, we find the expected benefits of collective teaching and collective learning, and also discover additional benefits of these two strategies, including the creation of a bridge network communication infrastructure. The study disclosed other conditions underlying the choice of strategies of transferring collective knowledge, including transfer effort and the level of group-embeddedness of the knowledge to be taught or re-embedded. The paper provides a group-level perspective in understanding organizational capabilities, as well as a set of refined constructs and propositions concerning strategic choices of transferring collective knowledge. The study also provides a rich description of the best practices and lessons learned in transferring organizational capabilities.knowledge transfer, collective knowledge, organizational capabilities, R&D capabilities, organizational learning, network, China

    Sensitivity analysis of wall-modeled large-eddy simulation for separated turbulent flow

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    In this study, we conduct a parametric analysis to evaluate the sensitivities of wall-modeled large-eddy simulation (LES) with respect to subgrid-scale (SGS) models, mesh resolution, wall boundary conditions and mesh anisotropy. While such investigations have been conducted for attached/flat-plate flow configurations, systematic studies specifically targeting turbulent flows with separation are notably sparse. To bridge this gap, our study focuses on the flow over a two-dimensional Gaussian-shaped bump at a moderately high Reynolds number, which involves smooth-body separation of a turbulent boundary layer under pressure-gradient and surface-curvature effects. In the simulations, the no-slip condition at the wall is replaced by three different forms of boundary condition based on the thin boundary layer equations and the mean wall-shear stress from high-fidelity numerical simulation to avoid the additional complexity of modeling the wall-shear stress. Various statistics, including the mean separation bubble size, mean velocity profile, and eddy viscosity from SGS model, are compared and analyzed. The results reveal that capturing the separation bubble strongly depends on the choice of SGS model. While grid convergence can be achieved at a resolution comparable to wall-resolved LES mesh, above this limit, the LES predictions exhibit intricate sensitivities to mesh resolution. Furthermore, both wall boundary conditions and the anisotropy of mesh cells exert discernible impacts on the turbulent flow predictions, yet the magnitudes of these impacts vary based on the specific SGS model chosen for the simulation

    Wall Modeling of Turbulent Flows with Various Pressure Gradients Using Multi-Agent Reinforcement Learning

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    We propose a framework for developing wall models for large-eddy simulation that is able to capture pressure-gradient effects using multi-agent reinforcement learning. Within this framework, the distributed reinforcement learning agents receive off-wall environmental states including pressure gradient and turbulence strain rate, ensuring adaptability to a wide range of flows characterized by pressure-gradient effects and separations. Based on these states, the agents determine an action to adjust the wall eddy viscosity, and consequently the wall-shear stress. The model training is in-situ with wall-modeled large-eddy simulation grid resolutions and does not rely on the instantaneous velocity fields from high-fidelity simulations. Throughout the training, the agents compute rewards from the relative error in the estimated wall-shear stress, which allows the agents to refine an optimal control policy that minimizes prediction errors. Employing this framework, wall models are trained for two distinct subgrid-scale models using low-Reynolds-number flow over periodic hills. These models are validated through simulations of flows over periodic hills at higher Reynolds numbers and flow over the Boeing Gaussian bump. The developed wall models successfully capture the acceleration and deceleration of wall-bounded turbulent flows under pressure gradients and outperform the equilibrium wall model in predicting skin friction.Comment: arXiv admin note: substantial text overlap with arXiv:2211.1642

    Accurate reconstruction of bacterial pan- and core genomes with PEPPAN

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    Bacterial genomes can contain traces of a complex evolutionary history, including extensive homologous recombination, gene loss, gene duplications and horizontal gene transfer. In order to reconstruct the phylogenetic and population history of a set of multiple bacteria, it is necessary to examine their pangenome, the composite of all the genes in the set. Here we introduce PEPPAN, a novel pipeline that can reliably construct pangenomes from thousands of genetically diverse bacterial genomes that represent the diversity of an entire genus. PEPPAN outperforms existing pangenome methods by providing consistent gene and pseudogene annotations extended by similarity-based gene predictions, and identifying and excluding paralogs by combining tree- and synteny-based approaches. The PEPPAN package additionally includes PEPPAN_parser, which implements additional downstream analyses including the calculation of trees based on accessory gene content or allelic differences between core genes. In order to test the accuracy of PEPPAN, we implemented SimPan, a novel pipeline for simulating the evolution of bacterial pangenomes. We compared the accuracy and speed of PEPPAN with four state-of-the-art pangenome pipelines using both empirical and simulated datasets. PEPPAN was more accurate and more specific than any of the other pipelines and was almost as fast as any of them. As a case study, we used PEPPAN to construct a pangenome of ~40,000 genes from 3052 representative genomes spanning at least 80 species of Streptococcus. The resulting gene and allelic trees provide an unprecedented overview of the genomic diversity of the entire Streptococcus genus

    Characterizing complication risk from multisite, intermittent transfusions for the treatment of sickle cell disease

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    Blood transfusions are indicated for some acute complications of sickle cell disease (SCD). To characterize the SCD population at increased risk of transfusion-associated complications, Geor-gia hospital discharge data were used to estimate the frequency of intermittent transfusions and the proportion of patients receiving them at multiple institutions. Ten years of data (2007-2016) showed almost 19% of patients with SCD (1585/8529) received transfusions at more than one hospital. The likelihood of multisite transfusions increased from ages 18 through 40 and with the number of transfusions received. The results support the need to track and share transfusion his-tories in order to reduce complication risks
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